Protective effects of methylprednisolone in kidney: aortic occlusion-reperfusion model in rats

Objectives: Ischemia/reperfusion (I/R) injury is commonly seen in cardiovascular surgery, activates inflammation and causes renal damage. In this experimental study, we aimed to assess the effects of different doses (5 30 mg/kg) methylprednisolone (MP), which has anti-inflammatory effect, on ischemia/reperfusion injury. Methods: Thirty-two male Wistar albino rats were randomly divided into four groups (n = 8). The sham group underwent midline laparotomy dissection abdominal aorta without occlusion while I/R suprarenal aortic ischemia for 45 minutes followed by 180 reperfusion. 5 mg/kg MP groups, was administered intraperitoneally. At end experiment, blood samples obtained, kidneys extracted. Results: Pretreatment with did not influence serum BUN creatinine levels. Serum TNF-α levels ischemia-modified albumin significantly lower compared (p < 0.05). Histological examination demonstrated severe treatment attenuated severity. difference significant MP. Conclusions: This results model presented work reveal protective cases I/R.